Publications and meeting abstracts

Recent meeting abstracts

iPSC-derived NK cells expressing the high affinity IgG Fc receptor fusion CD64/16A for optimized ADCC and multi-tumor antigen targeting
Kate Dixon, Kristin Snyder, Melissa Khaw, Robert Hullsiek, Zachary Davis, Anders Matson, Martin Hosking, Ryan Bjordahl, Bryan Hancock, Soheila Shirinbak, Jeffrey Miller, Bahram Valamehr, Jianming Wu and Bruce Walcheck
Effects of Blocking the Metalloprotease ADAM17 on the Generation of Cytokine Induced Memory-Like NK Cells
Robert Hullsiek, Anders Matson, Kate Dixon, Sam Wang and Bruce Walcheck
Inhibition of the regulatory checkpoint ADAM17 enhances NK cell proliferation by IL-15 through increased CD137 co-stimulation
Anders Matson, Rob Hullsiek, Kate Dixon, Ryan Friess, Sam Wang, Gwen Phung, Melissa Khaw, Martin Felices, Jianming Wu and Bruce Walcheck
IL-15-stimulated NK cell proliferation is greatly augmented by the anti-ADAM17 mAb Medi-1 and requires CD137
Anders Matson, Robert Hullsiek, Kate Dixon, Sam Wang, Ryan Friess, Bruce Walcheck

Publication highlights

iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting.

Snyder KM, Dixon KJ, Davis Z, Hosking M, Hart G, Khaw M, Matson A, Bjordahl R, Hancock B, Shirinbak S, Miller JS, Valamehr B, Wu J, Walcheck B., In: Dec 6 2023, J Immunother Cancer

graphic abstract




An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model

Jodi F. Hedges, Deann T. Snyder, Amanda Robison, Heather M. Grifka-Walk, Karlin Blackwell, Kelly Shepardson, Douglas Kominsky, Agnieszka Rynda-Apple, Bruce Walcheck, Mark A. Jutila, In: Jun 10 2022, Frontiers in immunology.

Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells

Robert Hullsiek, Yunfang Li, Kristin M. Snyder, Sam Wang, Da Di, Antonella Borgatti, Chae Lee, Peter F. Moore, Cong Zhu, Chiara Fattori, Jaime F. Modiano, Jianming Wu, Bruce Walcheck, In: Feb 24, 2022, Frontiers in immunology.

Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation

Mishra, H. K., Dixon, K., Pore, N., Felices, M., Miller, J. S. & Walcheck, B., Jul 22 2021, In: Frontiers in immunology. 12, 711621.

Research output: Contribution to journalArticlepeer-review

Engineering anti-tumor monoclonal antibodies and fc receptors to enhance ADCC by human NK cells

Dixon, K. J., Wu, J. & Walcheck, B., Jan 16 2021, In: Cancers. 13, 2, p. 1-13 13 p., 312.

Research output: Contribution to journalReview articlepeer-review

Ectodomain shedding by ADAM17 (a disintegrin and metalloproteinase 17) in canine neutrophils

Snyder, K. M. , McAloney, C. A. , Montel, J. S. , Modiano, J. F. & Walcheck, B. , Jan 1 2021 , In: Veterinary immunology and immunopathology. 231 , 110162. Research output : Contribution to journal › Article › peer-review

Blocking adam17 function with a monoclonal antibody improves sepsis survival in a murine model of polymicrobial sepsis

Hemant K. Mishra, Jing Ma, Daniel Mendez, Robert Hullsiek, Nabendu Pore, Bruce Walcheck, In: Int. J. Mol. Sci. 2020, 21(18), 6688;

Animal Science/Veterinary Medicine (AS/VM) Building