Publications and meeting abstracts

Meeting abstracts

• NK2023
• iPSC-derived NK cells expressing the high affinity IgG Fc receptor fusion CD64/16A for optimized ADCC and multi-tumor antigen targeting; Kate Dixon, Kristin Snyder, Melissa Khaw, Robert Hullsiek, Zachary Davis, Anders Matson, Martin Hosking, Ryan Bjordahl, Bryan Hancock, Soheila Shirinbak, Jeffrey Miller, Bahram Valamehr, Jianming Wu and Bruce Walcheck
• Effects of Blocking the Metalloprotease ADAM17 on the Generation of Cytokine Induced Memory-Like NK Cells; Robert Hullsiek, Anders Matson, Kate Dixon, Sam Wang and Bruce Walcheck
• Inhibition of the regulatory checkpoint ADAM17 enhances NK cell proliferation by IL-15 through increased CD137 co-stimulation; Anders Matson, Rob Hullsiek, Kate Dixon, Ryan Friess, Sam Wang, Gwen Phung, Melissa Khaw, Martin Felices, Jianming Wu and Bruce Walcheck
• SOCIETY FOR IMMUNOTHERAPY OF CANCER 
  IL-15-stimulated NK cell proliferation is greatly augmented by the anti-ADAM17 mAb Medi-1 and requires CD137; Anders Matson, Robert Hullsiek, Kate Dixon, Sam Wang, Ryan Friess, Bruce Walcheck

Publication highlights

• Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells. Matson AW, Hullsiek R, Dixon KJ, Wang S, Lindstedt AJ, Friess RR, Phung SK, Freedman TS, Felices M, Truckenbrod EN, Wu J, Miller JS, Walcheck B. 
• iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma. Dixon KJ, Snyder KM, Khaw M, Hullsiek R, Davis ZB, Matson AW, Shirinbak S, Hancock B, Bjordahl R, Hosking M, Miller JS, Valamehr B, Wu J, Walcheck B. 
• iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting. Snyder KM, Dixon KJ, Davis Z, Hosking M, Hart G, Khaw M, Matson A, Bjordahl R, Hancock B, Shirinbak S, Miller JS, Valamehr B, Wu J, Walcheck B., In: Dec 6 2023, J Immunother Cancer

• An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model; Jodi F. Hedges, Deann T. Snyder, Amanda Robison, Heather M. Grifka-Walk, Karlin Blackwell, Kelly Shepardson, Douglas Kominsky, Agnieszka Rynda-Apple, Bruce Walcheck, Mark A. Jutila, In: Jun 10 2022, Frontiers in immunology.
• Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells; Robert Hullsiek, Yunfang Li, Kristin M. Snyder, Sam Wang, Da Di, Antonella Borgatti, Chae Lee, Peter F. Moore, Cong Zhu, Chiara Fattori, Jaime F. Modiano, Jianming Wu, Bruce Walcheck, In: Feb 24, 2022, Frontiers in immunology.