Our research focus is on leukocyte biology and in particular on innate immune cells such as neutrophils and natural killer (NK) cells. Various receptors expressed on the surface of these cells that are critical for their function are regulated by a process known as “ectodomain shedding”, mediated by the metalloprotease ADAM17. We are actively studying this process to manipulate leukocyte function, such as to enhance tumor cell killing by NK cells.
Our lab has a long track record of NIH funding, collaborations with pharmaceutical and biotech companies, and generating intellectual property that has been utilized in clinical trials.
Animal Science/Veterinary Medicine (AS/VM) Building