Our research group is examining various aspects of inflammation and immune regulation. We are interested in mechanisms that direct white blood cells (leukocytes) to sites of inflammation and that regulate their function. A key leukocyte involved in the early events of inflammation is the neutrophil, the most abundant leukocyte in the blood. Another leukocyte of focus is the natural killer (NK) cell, which plays an important role in killing cancer cells. Various molecules expressed by these leukocytes are regulated by a process referred to as ectodomain shedding. Among other lines of research, our lab is actively involved in understanding the function and regulation of this proteolytic process in order to enhance immunity or decrease damaging inflammation.