Ectodomain Shedding




Ectodomain shedding is a proteolytic process occurring at the surface of cells that regulates the density of cell surface receptors and the release of soluble proinflammatory factors.  The a disintegrin and metalloprotease-17 (ADAM17), originally referred to as TNFalpha converting enzyme (TACE), is a key protease that mediates ectodomain shedding.  ADAM17 is constitutively expressed by leukocytes and its enzymatic activity is very rapidly induced upon their activation by various stimuli. 

Clinical relevance of ectodomain shedding